AKT1 抗体 102 文献

Rabbit Polyclonal| カタログ番号: 10176-2-AP

注目製品 KD/KO 検証済

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43,900円

(希望販売価格)

容量: 60 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
distributor

種特異性:
human, mouse, rat, zebrafish, A. sphaerocephala Krasch, chicken, hamster

WB ポジティブ:
HeLa cells, A549 cells, HepG2 cells, human liver tissue, mouse testis tissue

IP ポジティブ:
HeLa cells

IHC ポジティブ:
human ovary tumor tissue, human breast cancer tissue, human cervical cancer tissue

IF ポジティブ:
HeLa cells

FC ポジティブ:
HeLa cells

推奨希釈倍率:
WB : 1:500-1:1000
IP : 1:500-1:1000
IHC : 1:100-1:400
IF : 1:50-1:500

製品情報


由来:
Rabbit

精製方法:
Antigen affinity purification

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
v-akt murine thymoma viral oncogene homolog 1

計算分子量:
56 kDa

検出分子量:
56-62 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
AKT1

別名:
AKT, AKT1, PKB, PKB ALPHA, PRKBA, Protein kinase B, Proto oncogene c Akt, RAC, RAC ALPHA, RAC PK alpha
背景説明

The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.


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