APP 抗体 1 文献

Mouse Monoclonal| カタログ番号: 60342-1-Ig |クローン番号: 5C2A1

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43,900円

(希望販売価格)

容量: 168 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
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種特異性:
human, pig

WB ポジティブ:
Y79 cells, HEK-293 cells

IHC ポジティブ:
human gliomas tissue

推奨希釈倍率:
WB : 1:500-1:2000
IHC : 1:20-1:200

製品情報


由来:
Mouse

精製方法:
Protein A purification

アイソタイプ:
IgG2a

バッファー/保存方法:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
amyloid beta (A4) precursor protein

計算分子量:
86.9 kDa

検出分子量:
100 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
APP

別名:
A4, AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta
背景説明

Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).


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