acetylated Tubulin(Lys40) 抗体 5 文献

Mouse Monoclonal| カタログ番号: 66200-1-Ig |クローン番号: 7E5H8

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43,900円

(希望販売価格)

容量: 105 μg/150 μl

Choose quantity:

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適用アプリケーション

アプリケーション:
WB, IHC, IF, ELISA
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種特異性:
human, mouse, rat, dog, pig, Drosophila

WB ポジティブ:
L02 cells

IHC ポジティブ:
human lung cancer tissue, human gliomas tissue

IF ポジティブ:
MDCK cells

推奨希釈倍率:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:50-1:500

製品情報


由来:
Mouse

精製方法:
Protein G purification

アイソタイプ:
IgG1

バッファー/保存方法:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


免疫原:
Peptide

正式名:
tubulin, alpha 1a

計算分子量:
52 kDa

検出分子量:
55 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
TUBA1A

別名:
acetylated alpha tubulin, Acetylated tubulin, Acetylated tubulin (Lys40), acetylated-a-tubulin, acetyl-a-tubulin, alpha tubulin, Alpha tubulin 3, tubulin
背景説明

Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin. (24268707, 23881549)


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