CHOP 抗体 47 文献

Rabbit Polyclonal| カタログ番号: 15204-1-AP

注目製品 KD/KO 検証済

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43,900円

(希望販売価格)

容量: 56 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
distributor

種特異性:
human, mouse, rat, Hamster

WB ポジティブ:
RAW264.7 cells, HeLa cells, Tunicamycin treated HeLa cells, A375 cells, MCF-7 cells

IHC ポジティブ:
human cervical cancer tissue, human breast cancer tissue

FC ポジティブ:
HeLa cells

推奨希釈倍率:
WB : 1:500-1:2000
IHC : 1:50-1:200

製品情報


由来:
Rabbit

精製方法:
Antigen affinity purification

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
DNA-damage-inducible transcript 3

計算分子量:
19 kDa

検出分子量:
29 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
DDIT3

別名:
CEBPZ, CHOP, CHOP 10, DDIT 3, DDIT3, GADD153
背景説明

CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma. The calculated molecular weight of CHOP is 30 kDa. Immunoprecipitation of FUS-DDIT3 from the myxoid liposarcoma cell lines using an anti-DDIT3 antibody. FUS-DDIT3 is detected in cell lines at around 75 kDa (PMID: 27270875). The calculated molecular weight of CHOP is 19 kDa, but aproteintha tmigrateson SDS-PAGE with an apparent molecular mass of 29 kDa (PMID: 1547942).


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