PERK 抗体 3 文献

Rabbit Polyclonal| カタログ番号: 24390-1-AP

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43,900円

(希望販売価格)

容量: 50 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
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種特異性:
human

WB ポジティブ:
HepG2 cells

IHC ポジティブ:
human pancreas tissue, human placenta tissue

IF ポジティブ:
HepG2 cells

推奨希釈倍率:
WB : 1:200-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

製品情報


由来:
Rabbit

精製方法:
Antigen affinity purification

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
eukaryotic translation initiation factor 2-alpha kinase 3

計算分子量:
1116aa,125 kDa

検出分子量:
125 kDa, 140 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
EIF2AK3

別名:
EIF2AK3, HRI, HsPEK, Pancreatic eIF2 alpha kinase, PEK, PERK, WRS
背景説明

PERK is also named as PEK, EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3) and belongs to the GCN2 subfamily. It acts potentially as a metabolic sensor in the insulin-secreting beta-cells to modulate the trafficking and quality control of proinsulin in the ER relative to the physiological demands for circulating insulin(PMID:20530744).PERK and EIF2AK4 also have a functional role on regulating translation under non-stressed conditions, apart from their long established roles as stress kinases(PMID: 21638082). The full length protein has a signal peptide and a glycosylation site.


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