HMOX1 抗体 62 文献

Rabbit Polyclonal| カタログ番号: 10701-1-AP

注目製品 KD/KO 検証済

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43,900円

(希望販売価格)

容量: 59 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
distributor

種特異性:
human, mouse, rat

WB ポジティブ:
mouse liver tissue, HeLa cells, HepG2 cells, HT-1080 cells, rat spleen tissue

IP ポジティブ:
HeLa cells

IHC ポジティブ:
human liver cancer tissue, human kidney tissue

IF ポジティブ:
HT-1080 cells

推奨希釈倍率:
WB : 1:500-1:1000
IP : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:20-1:200

製品情報


由来:
Rabbit

精製方法:
Antigen affinity purification

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
heme oxygenase (decycling) 1

計算分子量:
33 kDa

検出分子量:
28-33 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
HMOX1

別名:
bK286B10, heme oxygenase (decycling) 1, Heme oxygenase 1, HMOX1, HO, HO 1, HO1, HSP32
背景説明

Heme oxygenase (HMOX1) catalyzes the first and rate-limiting step in the degradation of heme to yield equimolar quantities of biliverdin Ixa, carbon monoxide (CO), and iron. It has 3 isoforms: HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed (PMID:10194478). Heme oxygenase-1 (HO-1) is expressed in many tissues and vascular smooth muscle cells, and endothelial cells (PMID:15451051) and has been identified as an important endogenous protective factor induced in many cell types by various stimulants, such as hemolysis, infiammatory cytokines,oxidative stress, heat shock, heavy metals, and endotoxin (PMID: 11522663). And the full-length HO-1 is very unstable and susceptible to truncation that generates an inactive, soluble form (28 kDa) (James R. Reed, Pharmacology, 535-568).


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