TAU 抗体 3 文献

Rabbit Polyclonal| カタログ番号: 10274-1-AP

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43,900円

(希望販売価格)

容量: 35 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
distributor

種特異性:
human, mouse, rat

WB ポジティブ:
SH-SY5Y cells, HeLa cells, HT-1080 cells, rat brain tissue

IHC ポジティブ:
human brain tissue, human gliomas tissue, human lung cancer tissue

IF ポジティブ:
mouse brain tissue,

推奨希釈倍率:
WB : 1:300-1:1500
IHC : 1:20-1:200
IF : 1:50-1:500

製品情報


由来:
Rabbit

精製方法:
Antigen affinity purification

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
microtubule-associated protein tau

計算分子量:
37-46, 79-81 kDa

検出分子量:
66-70 kDa, 100 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
MAPT

別名:
DDPAC, FTDP 17, MAPT, MAPTL, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament tau, PHF tau, PPND, TAU
背景説明

The microtubule-associated protein TAU (MAPT or TAU) is encoded by MAPT gene, which locates on human chromosome 17q21, binds to the tubulin subunit of microtubule and promotes its assembly and stability. Most TAU is expressed in neurons, and TAU isoform is expressed in the peripheral nervous system while the others are expressed in the central nervous system. TAU links axonal microtubules with C-terminus to neural plasma membrane components with its N-terminus, suggesting the participation in intracellular signal transduction and neuron's development and viability. Various isoforms of TAU exist due to the alternative splicing, and short isoforms around 45-69 kDa and long isoforms around 100-110 kDa have been reported in different literature (8752131,15965697). Present polyclonal anti-MAPT antibody was produced by immunizing animals with N-terminal of MAPT and can detect approx 70-kDa and 100-kDa bands in brain tissues.


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