PARK7,DJ-1 抗体 4 文献

Rabbit Polyclonal| カタログ番号: 11681-1-AP

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43,900円

(希望販売価格)

容量: 82 μg/150 μl

Choose quantity:

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distributor

種特異性:
human, mouse

WB ポジティブ:
HeLa cells, HEK-293 cells, Jurkat cells

IP ポジティブ:
HeLa cells

IHC ポジティブ:
human gliomas tissue, human kidney tissue

IF ポジティブ:
SH-SY5Y cells

推奨希釈倍率:
WB : 1:500-1:2000
IP : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

製品情報


由来:
Rabbit

精製方法:
Antigen affinity purification

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
Parkinson disease (autosomal recessive, early onset) 7

計算分子量:
189aa,20 kDa

検出分子量:
20 kDa, 25 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
PARK7

別名:
DJ 1, DJ1, Oncogene DJ1, PARK7, Parkinson disease protein 7, Protein DJ 1
背景説明

PARK7, also named as DJ1, belongs to the peptidase C56 family. It protects cells against oxidative stress and cell death. PARK7 plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. It eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. PARK7 has cell-growth promoting activity and transforming activity. It may function as a redox-sensitive chaperone. It's precursor undergoes a cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress. The amino acid replace at 166 (L → P) reduces PARK7 protein stability and leads to increased degradation.


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