alpha-synuclein 抗体 10 文献

Rabbit Polyclonal| カタログ番号: 10842-1-AP

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43,900円

(希望販売価格)

容量: 76 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
distributor

種特異性:
human, mouse, rat

WB ポジティブ:
mouse brain tissue, human brain tissue, SH-SY5Y cells

IHC ポジティブ:
mouse brain tissue, human kidney tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue

IF ポジティブ:
SH-SY5Y cells, mouse brain tissue

推奨希釈倍率:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:10-1:100

製品情報


由来:
Rabbit

精製方法:
Antigen affinity purification

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
synuclein, alpha (non A4 component of amyloid precursor)

計算分子量:
14 kDa

検出分子量:
15-19 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
SNCA

別名:
Alpha synuclein, NACP, PARK1, PARK4, SNCA
背景説明

alpha-synuclein (α-syn) is a 14-19 kDa phosphoprotein that is primarily localize to the presynaptic terminals of mature neurons, where it is involved in synaptic function and plasticity. Α-syn has drawn intense interest ever since the late 1990s, when the first α-synuclein missense mutation was identified as a cause of familial Parkinson’s disease (PD). Aggregated and hyper-phosphorylated forms of α-syn protein are the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV). This antibody can recognize all the isoforms of α-syn.


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