TRAF4 Polyclonal antibody

TRAF4 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC,ELISA

Conjugate

Unconjugated

Cat no : 10083-2-AP

Synonyms

CART1, MLN 62, MLN62, RING finger protein 83, RNF83, TRAF4



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Published Applications

IHCSee 1 publications below

Product Information

10083-2-AP targets TRAF4 in IHC,ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TRAF4 fusion protein Ag0121 相同性解析による交差性が予測される生物種
Full Name TNF receptor-associated factor 4
Calculated molecular weight 54 kDa
GenBank accession numberBC001769
Gene symbol TRAF4
Gene ID (NCBI) 9618
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TRAF4 is the fourth member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with and mediate signal transduction from members of the TNF receptor superfamily. TRAF1 and TRAF2 are two related proteins that form a heterodimeric complex that associates with the cytoplasmic domain of the TNF-receptor type 2. The third member TRAF3 associates with the cytoplasmic domain of CD40. TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-KAPPA B activation. This protein also binds to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. TRAF4 thus, is thought to be involved in the oxidative activation of MAPK8/JNK.

Publications

SpeciesApplicationTitle
humanIHC

Cell Death Dis

Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness.

Authors - Yu-Chan Chang