• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human TGF beta 1 protein

Activity

Typically ≤ 0.5 ng/mL

Specific Activity

minimally 1.00 x 107 IU/mg

Species Reactivity

human,mouse,goat,pig,rat

Purity

>95%

Cat no : HZ-1011

Synonyms

CED, DPD1, LAP, TGF B1, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgf-beta1



Technical Specifications

GeneID 7040
Species Human
Expression HEK293
Activity Typically ≤ 0.5 ng/mL
Specific Activityminimally 1.00 x 107 IU/mg
Purity >95%
Endotoxin<1 EU/µg
Accession NumberP01137
Molecular Mass 13 kDa reduced, 25 kDa non-reduced, homodimer, non-glycosylated
Formulation 50 mM NaOAc pH 3.7, See Certificate of Analysis for details
Species Reactivity human,mouse,goat,pig,rat

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.

Background

TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, and cell differentiation. TGF acts synergistically with TGFA in inducing transformation process. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB having specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling being a potent stimulator of an osteoblastic bone formation (PMID: 11586292).

Synonyms

CED, DPD1, LAP, TGF B1, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgf-beta1

Publications

SpeciesTitle
human

Nature

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.

Authors - Lucia M Moreira
human

Nat Biotechnol

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.

Authors - DeepaSubramanyam
human

Immunity

Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis

Authors - Ruoxi Zhang
human

Cell Metab

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK

Authors - Yajuan Li
human

Nat Cell Biol

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.

Authors - Ji-Hyung Lee
human

ACS Nano

Deep-Learning-Based Nanomechanical Vibration for Rapid and Label-Free Assay of Epithelial Mesenchymal Transition

Authors - Wenjie Wu