ChromoTek LAG3 VHH, recombinant binding protein
Alpaca anti-LAG3 VHH, purified recombinant binding protein. Suitable for conjugation of dyes, biotin, beads, surfaces, etc. via NHS ester reaction
Cat no : lt
Synonyms
Validation Data Gallery
Product Information
Alpaca anti-LAG3 VHH, purified recombinant binding protein. Suitable for conjugation of dyes, biotin, beads, surfaces, etc. via NHS ester reaction
| Applications | Conjugation |
| Reactivity | Human |
| Conjugate | Unconjugated |
| Type | Nanobody |
| Class | Recombinant |
| Host | Alpaca |
| Affinity | in the picomolar range, below the assay limit (biolayer interferometry) |
| Molecular Weight | 15.141 kDa |
| RRID | / |
| Storage Buffer | 10 mM HEPES, 500 mM NaCl, pH 7.0, 1 mM TCEP |
| Storage Condition | Store at -20°C; Shipped at dry ice. |
| Background | LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703) |
Documentation
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| LAG3 VHH, recombinant binding protein SDS (PDF) |