ATF6 抗体 21 文献

Rabbit Polyclonal| カタログ番号: 24169-1-AP

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43,900円

(希望販売価格)

容量: 40 μg/150 μl

Choose quantity:

販売および在庫状況はコスモ・バイオ(株)にお問い合わせください。
distributor

種特異性:
human, rat, mouse

WB ポジティブ:
HeLa cells, MCF-7 cells, mouse liver tissue

IP ポジティブ:
HeLa cells

IHC ポジティブ:
human cervical cancer tissue, human pancreas tissue

IF ポジティブ:
HeLa cells

推奨希釈倍率:
WB : 1:500-1:2000
IP : 1:500-1:3000
IHC : 1:20-1:200
IF : 1:10-1:100

製品情報


由来:
Rabbit

精製方法:
Antigen Affinity purified

アイソタイプ:
IgG

バッファー/保存方法:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.

ターゲット情報


正式名:
activating transcription factor 6

計算分子量:
75 kDa

検出分子量:
90-100 kDa

GenBank accession number:

Gene ID (NCBI):

遺伝子シンボル:
ATF6

別名:
ATF6, ATF6 alpha, ATF6A
背景説明

Activating transcription factor 6 (ATF6) is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases. The fully glycosylated form of ATF6, a 670 amino acid protein, exhibits an electrophoretic mobility of ~90 kDa in denaturing SDS-gels, in part because of the glycosylated modifications. ATF6 has 3 consensus sites for N-linked glycosylation and exists constitutively as a glycosylated protein. Differentially glycosylated ATF6 forms may result from mutations or experimental treatment (PMID:15804611) (PMID:14699159). The antibody recognizes cleaved and fully glycosylated forms of ATF6.


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