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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

ABCC5 Monoclonal antibody, PBS Only

ABCC5 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H10F11

Cat no : 67955-1-PBS

Synonyms

ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using ABCC5 Monoclonal antibody (67955-1-Ig)

    WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    Boiled and unboiled HepG2 lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using ABCC5 Monoclonal antibody (67955-1-Ig)

    WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

67955-1-PBS targets ABCC5 in WB, Indirect ELISA applications and shows reactivity with Human, Rat samples.

Tested Reactivity Human, Rat
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen ABCC5 fusion protein Ag31674 相同性解析による交差性が予測される生物種
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Calculated molecular weight 161 kDa
Observed molecular weight180-200kDa
GenBank accession numberNM_005688
Gene symbol ABCC5
Gene ID (NCBI) 10057
RRIDAB_2918706
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

ABCC5, also named as MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).