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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

ACVR1 Monoclonal antibody, PBS Only

ACVR1 Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Pig, Mouse, Rat

Applications

WB, IHC, IF-P, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1F11B10

Cat no : 67417-1-PBS

Synonyms

activin A receptor, type I, Activin receptor like kinase 2, Activin receptor type 1, Activin receptor type I, ACTR I, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK 2, ALK2, FOP, SKR1, TSR I, TSRI

Validation Data Gallery

Filter:
  • Western Blot (WB) analysis of various lysates using ACVR1 Monoclonal antibody (67417-1-Ig)

    WB analysis using 67417-1-Ig (same clone as 67417-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67417-1-Ig (ACVR1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat brain tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    WB analysis of rat brain using 67417-1-Ig (same clone as 67417-1-PBS)

    rat brain tissue were subjected to SDS PAGE followed by western blot with 67417-1-Ig (ACVR1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of pig brain tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    WB analysis of pig brain using 67417-1-Ig (same clone as 67417-1-PBS)

    pig brain tissue were subjected to SDS PAGE followed by western blot with 67417-1-Ig (ACVR1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using ACVR1 Monoclonal antibody (67417-1-Ig)

    WB analysis using 67417-1-Ig (same clone as 67417-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67417-1-Ig (ACVR1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse heart tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse heart tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    IHC staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    IHC staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of mouse brain tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using ACVR1 antibody (67417-1-Ig, Clone: 1F11B10 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of mouse brain tissue using ACVR1 Monoclonal antibody (67417-1-Ig)

    IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using ACVR1 antibody (67417-1-Ig, Clone: 1F11B10 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

67417-1-PBS targets ACVR1 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human, Pig, Mouse, Rat samples.

Tested Reactivity Human, Pig, Mouse, Rat
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen ACVR1 fusion protein Ag13508 相同性解析による交差性が予測される生物種
Full Name activin A receptor, type I
Calculated molecular weight 509 aa, 57 kDa
Observed molecular weight 57 kDa
GenBank accession numberBC033867
Gene symbol ACVR1
Gene ID (NCBI) 90
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).