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ACVR1B Polyclonal antibody

ACVR1B Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 10086-1-AP

Synonyms

activin A receptor, type IB, Activin receptor like kinase 4, Activin receptor type 1B, Activin receptor type IB, ACTR IB, ACTRIB, ACVR1B, ACVRLK4, ALK 4, ALK4, SKR2


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Tested Applications

Positive WB detected inHEK-293 cells, DMSO treated HepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10086-1-AP targets ACVR1B in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ACVR1B fusion protein Ag0129 相同性解析による交差性が予測される生物種
Full Name activin A receptor, type IB
Calculated molecular weight 57 kDa
Observed molecular weight50 kDa
GenBank accession numberBC000254
Gene symbol ACVR1B
Gene ID (NCBI) 91
RRIDAB_2877723
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

ACVR1B (ALK4, activin A receptor type 1B) is a transforming growth factor-beta (TGF-beta) superfamily member (PMID: 37020544). A potential role for ACVR1B in regulating muscle mass is that it is part of the transforming growth factor b (TGFb) pathway regulating myostatin (PMID: 21063444).

Protocols

Product Specific Protocols
WB protocol for ACVR1B antibody 10086-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB,IHC,IF

J Am Heart Assoc

Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy.

Authors - Qian Wang
mouseWB,IF

Mol Cell Endocrinol

ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.

Authors - Li Ma
humanWB

Animals (Basel)

Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B.

Authors - Xin Hu
humanWB

Reprod Biol Endocrinol

PMID: 29925391

Authors - Cheng Li
ratWB

J Toxicol Sci

Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway.

Authors - Zhenjian Lin
ratWB

Bioact Mater

Bioprinted constructs that simulate nerve-bone crosstalk to improve microenvironment for bone repair

Authors - Tianchang Wang