ADRB2 Polyclonal antibody
ADRB2 Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human and More (2)
Applications
WB, ELISA
Conjugate
Unconjugated
Cat no : 29864-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | A549 cells |
Recommended dilution
Application | Dilution |
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Western Blot (WB) | WB : 1:500-1:3000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Published Applications
WB | See 3 publications below |
Product Information
29864-1-AP targets ADRB2 in WB, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Cited Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | ADRB2 fusion protein Ag32313 相同性解析による交差性が予測される生物種 |
Full Name | adrenergic, beta-2-, receptor, surface |
Calculated molecular weight | 46 kDa |
Observed molecular weight | 46-48 kDa |
GenBank accession number | BC012481 |
Gene symbol | ADRB2 |
Gene ID (NCBI) | 154 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Beta-2 adrenergic receptor (ADRB2), a member of the G protein-coupled receptor (GPCR) family, binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ADRB2 is directly linked to one of its final effectors, the class C L-type Ca2+ channel, Cav1.2 (PMID: 11441182). This receptor-channel complex also contains a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase (PKA), and a counteracting phosphatase, PP2A. Different polymorphic forms, point mutations, and/or downregulation of the gene of ADRB2 are associated with nocturnal asthma, obesity, and type 2 diabetes. This antibody detects ADRB2 with a molecular weight of 46-48 kDa as has been shown by some researches (PMID: 30542705; 35075132).
Protocols
Product Specific Protocols | |
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WB protocol for ADRB2 antibody 29864-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
Publications
Species | Application | Title |
---|---|---|
iScience Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration | ||
Oncol Lett β‑adrenergic receptor activation promotes the proliferation of HepG2 cells via the ERK1/2/CREB pathways | ||
Immunobiology Exploring liquid-liquid phase separation-related diagnostic biomarkers in osteoarthritis based on machine learning algorithms and experiment |