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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

AGTR1 Monoclonal antibody, PBS Only

AGTR1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse, rat, pig

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2C5G11

Cat no : 66415-1-PBS

Synonyms

Angiotensin II type-1 receptor, Angiotensin II type 1 receptor, AGTR1B, AGTR1A, AG2S

Validation Data Gallery

Filter:
  • Western Blot (WB) analysis of pig heart tissue using AGTR1 Monoclonal antibody (66415-1-Ig)

    WB analysis of pig heart using 66415-1-Ig (same clone as 66415-1-PBS)

    pig heart tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat heart tissue using AGTR1 Monoclonal antibody (66415-1-Ig)

    WB analysis of rat heart using 66415-1-Ig (same clone as 66415-1-PBS)

    rat heart tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of pig skeletal muscle tissue using AGTR1 Monoclonal antibody (66415-1-Ig)

    WB analysis of pig skeletal muscle using 66415-1-Ig (same clone as 66415-1-PBS)

    pig skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

66415-1-PBS targets AGTR1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

Tested Reactivity human, mouse, rat, pig
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen AGTR1 fusion protein Ag14461 相同性解析による交差性が予測される生物種
Full Name angiotensin II receptor, type 1
Calculated molecular weight 359 aa, 41 kDa
Observed molecular weight 50 kDa
GenBank accession numberBC022447
Gene symbol AGTR1
Gene ID (NCBI) 185
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role (PMID: 21600887). AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression (PMID: 26975580).