- Featured Product
- KD/KO Validated
APP Monoclonal antibody, PBS Only
APP Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human, rat, pig, rabbit
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
5C2A1
Cat no : 60342-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
60342-1-PBS targets APP in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat, pig, rabbit samples.
Tested Reactivity | human, rat, pig, rabbit |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | APP fusion protein Ag0769 相同性解析による交差性が予測される生物種 |
Full Name | amyloid beta (A4) precursor protein |
Calculated molecular weight | 87 kDa |
Observed molecular weight | 100 kDa |
GenBank accession number | BC004369 |
Gene symbol | APP |
Gene ID (NCBI) | 351 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).