AUTS2 Polyclonal antibody
AUTS2 Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, IF, ChIP, ELISA
Conjugate
Unconjugated
Cat no : 25001-1-AP
Synonyms
Validation Data Gallery
Tested Applications
| Positive WB detected in | C6 cells, NIH/3T3 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| WB | See 2 publications below |
| IF | See 3 publications below |
| ChIP | See 1 publications below |
Product Information
The immunogen of 25001-1-AP is AUTS2 Fusion Protein expressed in E. coli.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | AUTS2 fusion protein Ag21853 相同性解析による交差性が予測される生物種 |
| Full Name | autism susceptibility candidate 2 |
| Calculated molecular weight | 139 kDa |
| Observed molecular weight | 70 kDa, 130-140 kDa |
| GenBank accession number | BC064693 |
| Gene symbol | AUTS2 |
| Gene ID (NCBI) | 26053 |
| RRID | AB_2879840 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
AUTS2 also named as FBRSL2 or autism susceptibility candidate 2 is a 1259 amino acid protein, which belongs to the AUTS2 family. AUTS2 is highly expressed in brain, kidney and skeletal muscle. AUTS2 exists as four isoforms produced by alternative splicing events and is encoded by a gene located on human chromosome 7. The molecular weight of AUTS2 isoform is 65-70 kDa in the brain ( PMID:23332918). The functional role of AUTS2 is not well known, although some studies have identified a putative role in transcriptional regulation during neuronal development.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for AUTS2 antibody 25001-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Front Neurol Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model. | ||
Mol Cell Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities. | ||
Exp Neurol Auts2 regulated autism-like behavior, glucose metabolism and oxidative stress in mice | ||
Nucleic Acids Res CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver |
