- Featured Product
- KD/KO Validated
Alix Monoclonal antibody, PBS Only
Alix Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse, Rat
Applications
WB, IF/ICC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1H9D9
Cat no : 67715-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
67715-1-PBS targets Alix in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
Tested Reactivity | Human, Mouse, Rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | Alix fusion protein Ag30437 相同性解析による交差性が予測される生物種 |
Full Name | programmed cell death 6 interacting protein |
Calculated molecular weight | 868 aa, 96 kDa |
Observed molecular weight | 100 kDa |
GenBank accession number | BC020066 |
Gene symbol | Alix |
Gene ID (NCBI) | 10015 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
ALG-2-interacting protein 1 (ALIX), also known as AIP1 or Hp95, is encoded by PDCD6IP gene and is involved in cell death through mechanisms involving its binding partner ALG-2 (apoptosis-linked gene-2). ALG-2 is a 22-kDa protein containing five serially repetitive EF-hand structures and is defined as a regulator of calcium-induced apoptosis following endoplasmic reticulum (ER) stress. ALIX interacts with ALG-2 through its C-terminal proline-rich region and participates in formation of multivesicular bodies. Recent finding suggest that ALIX is a critical component of caspase 9 activation and apoptosis triggered by calcium.