Amphiregulin Monoclonal antibody, PBS Only
Amphiregulin Monoclonal Antibody for WB, IHC, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, rat, pig
Applications
WB, IHC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1A1G9
Cat no : 66433-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66433-1-PBS targets Amphiregulin in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat, pig samples.
Tested Reactivity | human, rat, pig |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | Amphiregulin fusion protein Ag8907 相同性解析による交差性が予測される生物種 |
Full Name | amphiregulin |
Calculated molecular weight | 252 aa, 28 kDa |
Observed molecular weight | 50 kDa, 37 kDa |
GenBank accession number | BC009799 |
Gene symbol | Amphiregulin/AREG |
Gene ID (NCBI) | 374 |
RRID | AB_2881803 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms (PMID: 9642297).