Validation Data Gallery
Filter:
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
25891-1-PBS targets C9 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C9 fusion protein Ag23137 相同性解析による交差性が予測される生物種 |
| Full Name | complement component 9 |
| Calculated molecular weight | 559 aa, 63 kDa |
| Observed molecular weight | 64 kDa |
| GenBank accession number | BC020721 |
| Gene Symbol | C9 |
| Gene ID (NCBI) | 735 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P02748 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
The final consequence of complement activation is the formation of the membrane attack complex (MAC), a multiprotein assembly that perforates cell membranes, forming transmembrane channels. The MAC plays a critical role in complement-mediated hemolysis and inflammasome activation (PMID: 27444648). Complement component 9 (C9) is 1 of 5 late-acting proteins of complement that participate in the assembly and function of the MAC. C9 may be cleaved by thrombin to generate fragments C9a (25 kDa) and C9b (37 kDa) (PMID: 7523406).