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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Mouse CD11c (N418) Mouse IgG2a Recombinant Antibody

CD11c Recombinant Antibody for FC

Host / Isotype

Mouse / IgG2a

Reactivity

Mouse

Applications

FC

Conjugate

Unconjugated

CloneNo.

N418

Cat no : 65602-1-MR

Synonyms

AI449405, Cd11c, Cr4, integrin alpha X, Itgax

Validation Data Gallery

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  • Flow cytometry (FC) experiment of mouse splenocytes using Anti-Mouse CD11c (N418) Mouse IgG2a Recombinant An (65602-1-MR)

    FC experiment of mouse splenocytes using 65602-1-MR

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD11c (N418) Mouse IgG2a Recombinant Antibody (65602-1-MR, Clone: N418) (right), or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (left) and FITC anti-mouse IgG2a Antibody. Cells well then stained with APC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2) (APC-65122, Clone: M5/114.15.2). Cells were not fixed.

  • Flow cytometry (FC) experiment of mouse splenocytes using Anti-Mouse CD11c (N418) Mouse IgG2a Recombinant An (65602-1-MR)

    FC experiment of mouse splenocytes using 65602-1-MR

    1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD11c (N418) Mouse IgG2a Recombinant Antibody (65602-1-MR, Clone: N418) (right), or 0.25 ug Anti-Mouse CD11c (N418) (65130-1-Ig, Clone: N418) (left) and FITC anti-mouse IgG2a Antibody. Cells well then stained with APC Anti-Mouse MHC Class II (I-A/I-E) (M5/114.15.2) (APC-65122, Clone: M5/114.15.2). Cells were not fixed.

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Tested Applications

Positive FC detected inmouse splenocytes

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65602-1-MR targets CD11c in FC applications and shows reactivity with Mouse samples.

Tested Reactivity Mouse
Host / Isotype Mouse / IgG2a
Class Recombinant
Type Antibody
Immunogen Mouse spleen dendritic cells 相同性解析による交差性が予測される生物種
Full Name integrin alpha X
GenBank accession numberBC167225
Gene symbol CD11c
Gene ID (NCBI) 16411
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.09% sodium azide.
Storage ConditionsStore at 2-8°C. Stable for one year after shipment.

Background Information

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).

Protocols

Product Specific Protocols
FC protocol for CD11c antibody 65602-1-MRDownload protocol
Standard Protocols
Click here to view our Standard Protocols