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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Human CD134/OX40 Rabbit Recombinant Antibody, PBS Only

CD134/OX40 Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241398G7

Cat no : 98181-1-PBS

Synonyms

TNFRSF4, OX40L receptor, OX40, CD134, ACT35 antigen

Validation Data Gallery

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  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR)

    FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

    1x10^6 untreated or PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Human CD4 (RPA-T4) (APC-65143, Clone: RPA-T4). Cells were not fixed. This data was developed using the same antibody clone with 98181-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR)

    FC experiment of human PBMCs using 98181-1-RR (same clone as 98181-1-PBS)

    1x10^6 PHA-treated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) (red) or Isotype Control (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human CD134/OX40 Rabbit Recombinant Antibody (98181-1-RR, Clone: 241398G7) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98181-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98181-1-RR

    Affinity and Kinetic Characterization of 98181-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98181-1-RR against Human CD134/OX40 were performed. The affinity constant is 5.48 nM.

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Tested Applications

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

98181-1-PBS targets CD134/OX40 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name tumor necrosis factor receptor superfamily, member 4
Calculated molecular weight 29 kDa
GenBank accession numberNM_003327
Gene symbol CD134
Gene ID (NCBI) 7293
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).