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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Human CD141/Thrombomodulin Rabbit Recombinant Antibody, PBS Only

CD141/Thrombomodulin Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

240365H3

Cat no : 98037-2-PBS

Synonyms

THBD, Thrombomodulin, THRM, Fetomodulin, CD141

Validation Data Gallery

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  • Flow cytometry (FC) experiment of human peripheral blood leukocytes using Anti-Human CD141/Thrombomodulin Rabbit Recombinant (98037-2-RR)

    FC experiment of human peripheral blood leukocytes using 98037-2-RR (same clone as 98037-2-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human Thrombomodulin Rabbit Recombinant Antibody (98037-2-RR, Clone: 240365H3) or 0.25 ug Control Antibody, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98037-2-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human peripheral blood leukocytes using Anti-Human CD141/Thrombomodulin Rabbit Recombinant (98037-2-RR)

    FC experiment of human peripheral blood leukocytes using 98037-2-RR (same clone as 98037-2-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human Thrombomodulin Rabbit Recombinant Antibody (98037-2-RR, Clone: 240365H3) (red) or 0.25 ug Control Antibody (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98037-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98037-2-RR

    Affinity and Kinetic Characterization of 98037-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98037-2-RR against Human CD141/Thrombomodulin were performed. The affinity constant is 0.684 nM.

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Tested Applications

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

The immunogen of 98037-2-PBS is CD141/Thrombomodulin Fusion Protein expressed in E. coli.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Fusion Protein 相同性解析による交差性が予測される生物種
Full Name thrombomodulin
Calculated molecular weight60 kDa
GenBank accession numberNM_000361.3
Gene symbol THBD
Gene ID (NCBI) 7056
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310).