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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

CD41/Integrin alpha 2b Polyclonal antibody, PBS Only

CD41/Integrin alpha 2b Polyclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 18308-1-PBS

Synonyms

Validation Data Gallery

Filter:
  • Immunohistochemistry (IHC) staining of mouse spleen tissue using CD41/Integrin alpha 2b Polyclonal antibody (18308-1-AP)

    IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 18308-1-AP (CD41/Integrin alpha 2b antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse spleen tissue using CD41/Integrin alpha 2b Polyclonal antibody (18308-1-AP)

    IHC staining of mouse spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 18308-1-AP (CD41/Integrin alpha 2b antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human spleen tissue using CD41/Integrin alpha 2b Polyclonal antibody (18308-1-AP)

    IHC staining of human spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 18308-1-AP (CD41/Integrin Alpha 2B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human spleen tissue using CD41/Integrin alpha 2b Polyclonal antibody (18308-1-AP)

    IHC staining of human spleen using 18308-1-AP (same clone as 18308-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 18308-1-AP (CD41/Integrin Alpha 2B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18308-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

18308-1-PBS targets CD41/Integrin alpha 2b in IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide 相同性解析による交差性が予測される生物種
Full Name integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Calculated molecular weight 113 kDa
GenBank accession numberBC126442
Gene symbol CD41a
Gene ID (NCBI) 3674
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light (25 kDa) and heavy (125 kDa) chains which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen.