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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Human CD98/SLC3A2 Rabbit Recombinant Antibody

CD98/SLC3A2 Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241755D6

Cat no : 98190-1-RR

Synonyms

CD98, SLC3A2, MDU1, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain

Validation Data Gallery

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  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human CD98/SLC3A2 Rabbit Recombinant Antibody (98190-1-RR)

    FC experiment of human PBMCs using 98190-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human CD98/SLC3A2 Rabbit Recombinant Antibody (98190-1-RR)

    FC experiment of human PBMCs using 98190-1-RR

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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Tested Applications

Positive FC detected inhuman PBMCs

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98190-1-RR targets CD98/SLC3A2 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Calculated molecular weight68kDa
GenBank accession numberNM_002394.5
Gene symbol CD98
Gene ID (NCBI) 6520
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

Background Information

CD98 is a 125-kDa type II membrane glycoprotein heterodimer composed of a 40-kDa non-glycosylated light chain (amino-acid transporter, encoded by the SLC7A5) and an 85-kDa glycosylated heavy chain (CD98hc, encoded by the SLC3A2) (PMID: 11507094). CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). Molecular orientation studies have demonstrated that the C-terminal tail of human CD98 (hCD98), which contains a PDZ-binding domain, is extracellular (PMID: 18625289).

Protocols

Product Specific Protocols
FC protocol for CD98/SLC3A2 antibody 98190-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols