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- KD/KO Validated
CEP68 Polyclonal antibody
CEP68 Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IF, ELISA
Conjugate
Unconjugated
Cat no : 15147-1-AP
Synonyms
Validation Data Gallery
Tested Applications
| Positive WB detected in | SH-SY5Y cells, HeLa cells, Jurkat cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:4000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 4 publications below |
| WB | See 6 publications below |
| IF | See 6 publications below |
Product Information
15147-1-AP targets CEP68 in WB, IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CEP68 fusion protein Ag7447 相同性解析による交差性が予測される生物種 |
| Full Name | centrosomal protein 68kDa |
| Calculated molecular weight | 81 kDa |
| Observed molecular weight | 68 kDa |
| GenBank accession number | BC002982 |
| Gene symbol | CEP68 |
| Gene ID (NCBI) | 23177 |
| RRID | AB_2077081 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
CEP68, or centrosomal protein 68, is a protein-coding gene in humans. It is involved in the maintenance of centrosome cohesion, likely as part of a linker structure that prevents centrosome splitting. CEP68 is also required for the localization of CDK5RAP2 to the centrosome during interphase and contributes to the formation of CROCC/rootletin filaments. This protein is encoded by the CEP68 gene and is located on the fibers emanating from the proximal ends of centrioles. It has been associated with diseases such as Retinitis Pigmentosa 28 and is implicated in angioedema. The gene is mapped to chromosome 2 and is expressed ubiquitously in various tissues, including the brain, ovary, and others. The protein plays a crucial role in cellular functions related to the centrosome, which is a key organelle in cell division and organization
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for CEP68 antibody 15147-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
J Virol The Cytoskeletal Adaptor Obscurin-Like 1 Interacts with the Human Papillomavirus 16 (HPV16) Capsid Protein L2 and Is Required for HPV16 Endocytosis.
| ||
Sci Rep Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins | ||
iScience Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement. |
