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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

CLN3 Monoclonal antibody, PBS Only

CLN3 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1E10A9

Cat no : 67957-1-PBS

Synonyms

Batten disease protein, BATTENIN, BTS, CLN3, JNCL, Protein CLN3

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CLN3 Monoclonal antibody (67957-1-Ig)

    WB analysis using 67957-1-Ig (same clone as 67957-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67957-1-Ig (CLN3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 67957-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLN3 Monoclonal antibody (67957-1-Ig)

    WB analysis using 67957-1-Ig (same clone as 67957-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67957-1-Ig (CLN3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67957-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

67957-1-PBS targets CLN3 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen CLN3 fusion protein Ag31402 相同性解析による交差性が予測される生物種
Full Name ceroid-lipofuscinosis, neuronal 3
Calculated molecular weight 438 aa, 48 kDa
Observed molecular weight50 kDa
GenBank accession numberBC002394
Gene symbol CLN3
Gene ID (NCBI) 1201
RRIDAB_2918708
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Neuronal ceroid lipofuscinosis (NCL, or Batten disease) refers to a group of lethal pediatric neurodegenerative diseases originating from mutations in one of the thus far identified 13 CLN genes (Ceroid Lipofuscinosis, Neuronal type; CLN1 to CLN14) (PMID: 25051496). CLN3 is a multi-membrane spanning protein that is involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. The CLN3 gene is located on chromosome 16p12.1and produces three mRNA splicing variants. The 438-amino-acid CLN3 protein has a calculated molecular weight of 48 kDa. It has been reported that CLN3 can be glycosylated and form homodimeric complex (PMID: 10356317; 17286803).