CNTN1 Monoclonal antibody
CNTN1 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, pig, rabbit
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
1C1D4
Cat no : 68252-1-Ig
Synonyms
Validation Data Gallery
Tested Applications
| Positive WB detected in | A549 cells, pig cerebellum tissue, pig brain tissue, rabbit brain tissue, rabbit cerebellum tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
68252-1-Ig targets CNTN1 in WB, ELISA applications and shows reactivity with Human, pig, rabbit samples.
| Tested Reactivity | Human, pig, rabbit |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CNTN1 fusion protein Ag5030 相同性解析による交差性が予測される生物種 |
| Full Name | contactin 1 |
| Calculated molecular weight | 1018 aa, 113 kDa |
| Observed molecular weight | 130-135 kDa |
| GenBank accession number | BC036569 |
| Gene symbol | CNTN1 |
| Gene ID (NCBI) | 1272 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Contactin-1 (CNTN1), also known as Glycoprotein gp135 or Neural cell surface protein F3, is a neuronal cell adhesion molecule of the immunoglobulin superfamily (PMID: 3049624). It consists of six Ig domains, four fibronectin-like motifs, and a glycosylphosphatidylinositol (GPI)-moiety. Expressed by the central and peripheral neurons, CNTN1 contributes to the formation and function of neuronal connections. It plays a role in axon extension and formation of septate-like junctions between axons and myelinating glial cells (PMID: 23724143). In addition, acting as a ligand for Notch, CNTN1 initiates a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination (PMID: 14567914).
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for CNTN1 antibody 68252-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
