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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CXCR3 Recombinant antibody (84655-5-RR)

    WB analysis using 84655-5-RR (same clone as 84655-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84655-5-RR (CXCR3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat liver tissue using CXCR3 Recombinant antibody (84655-5-RR)

    WB analysis of rat liver using 84655-5-RR (same clone as 84655-5-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 84655-5-RR (CXCR3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse liver tissue using CXCR3 Recombinant antibody (84655-5-RR)

    IHC staining of mouse liver using 84655-5-RR (same clone as 84655-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 84655-5-RR (CXCR3 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84655-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84655-5-RR

    Affinity and Kinetic Characterization of 84655-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84655-5-RR against Human CXCR3 were performed. The affinity constant is 1.84 nM.

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CXCR3 Recombinant antibody, PBS Only

CXCR3 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 84655-5-PBS
Clone No.241790E9

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

CMKAR3, CKR-L2, CKR L2, CD183, CD182

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

84655-5-PBS targets CXCR3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name chemokine (C-X-C motif) receptor 3
Calculated molecular weight 368 aa, 41 kDa
Observed molecular weight45 kDa
GenBank accession numberBC034403
Gene Symbol CXCR3
Gene ID (NCBI) 2833
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP49682
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of several cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. The binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586). Alternatively, spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as a functional receptor for CXCL4 (PMID:12782716).