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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody, PBS Only

CXCR4/CD184 Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241735F8

Cat no : 98175-1-PBS

Synonyms

CXCR4, CXCR 4, CXC R4, C-X-C chemokine receptor type 4, CD184

Validation Data Gallery

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  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody (98175-1-RR)

    FC experiment of human PBMCs using 98175-1-RR (same clone as 98175-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody (98175-1-RR, Clone: 241735F8),or Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98175-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody (98175-1-RR)

    FC experiment of human PBMCs using 98175-1-RR (same clone as 98175-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CXCR4/CD184 Rabbit Recombinant Antibody (98175-1-RR, Clone:241735F8)(red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98175-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

98175-1-PBS targets CXCR4/CD184 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant Protein 相同性解析による交差性が予測される生物種
Full Name chemokine (C-X-C motif) receptor 4
Calculated molecular weight 352 aa, 40 kDa
GenBank accession numberBC020968
Gene symbol CXCR4
Gene ID (NCBI) 7852
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

C-X-C chemokine receptor type 4 (CXCR4, also known as CD184) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609).