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- KD/KO Validated
Caspase 8/p43/p18 Monoclonal antibody, PBS Only
Caspase 8/p43/p18 Monoclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
human
Applications
WB, IHC, IF/ICC, IP, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2B9H8
Cat no : 66093-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66093-1-PBS targets Caspase 8/p43/p18 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | Caspase 8/p43/p18 fusion protein Ag20524 相同性解析による交差性が予測される生物種 |
Full Name | caspase 8, apoptosis-related cysteine peptidase |
Calculated molecular weight | 538 aa, 62 kDa |
Observed molecular weight | 53-57 kDa, 32-45 kDa, 18 kDa |
GenBank accession number | BC028223 |
Gene symbol | Caspase 8 |
Gene ID (NCBI) | 841 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3 (PMID:21816816). It may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway (PMID:19194987). Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibody can recognize pro- and cleaved-caspase 8.