Collagen Type XI Polyclonal antibody
Collagen Type XI Polyclonal Antibody for IHC, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
IF, IHC, ELISA
Conjugate
Unconjugated
Cat no : 21841-1-AP
Synonyms
Validation Data Gallery
Tested Applications
| Positive IHC detected in | human placenta tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| IHC | See 4 publications below |
| IF | See 3 publications below |
Product Information
21841-1-AP targets Collagen Type XI in IF, IHC, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Collagen Type XI fusion protein Ag16509 相同性解析による交差性が予測される生物種 |
| Full Name | collagen, type XI, alpha 1 |
| Calculated molecular weight | 1818 aa, 182 kDa |
| GenBank accession number | BC117697 |
| Gene symbol | COL11A1 |
| Gene ID (NCBI) | 1301 |
| RRID | AB_2918074 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
COL11A1 is an important component of collagen XI and is considered to play an important role in a variety of connective tissue diseases. Type XI collagen is widely distributed in tissues including cartilage, bone, and muscle, and its hereditary absence in Marshall's syndrome, Stickler's syndrome, fibrochondrogenesis, and nonsyndromic hearing loss deafness, autosomal dominant 37 leads to facial and eye abnormalities, hearing loss, and joint problems. The COL11A1 expression was significantly correlated with the degree of immune infiltration and the expression of a variety of immune cell markers in tumor tissue. (PMID: 36160004 33610546)
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for Collagen Type XI antibody 21841-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Transl Oncol Multiregion single cell analysis reveals a novel subtype of cancer-associated fibroblasts located in the hypoxic tumor microenvironment in colorectal cancer | ||
J Orthop Res Increased Wnt5a/ROR2 signaling is associated with chondrogenesis in meniscal degeneration | ||
BMC Med Genomics Analysis of cancer-associated fibroblasts related genes identifies COL11A1 associated with lung adenocarcinoma prognosis | ||
Front Immunol COL11A1 as an novel biomarker for breast cancer with machine learning and immunohistochemistry validation | ||
