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Cyclin D1 Monoclonal antibody, PBS Only

Cyclin D1 Monoclonal Antibody for WB, FC (Intra), ELISA
Cat No. 60186-1-PBS
Clone No.2G3G5

Host / Isotype

Mouse / IgG2b

Reactivity

human, mouse

Applications

WB, FC (Intra), ELISA

CCND1, BCL-1 oncogene, BCL-1, B-cell lymphoma 1 protein, B cell lymphoma 1 protein

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -


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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

60186-1-PBS targets Cyclin D1 in WB, FC (Intra), ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen Cyclin D1 fusion protein Ag0689 相同性解析による交差性が予測される生物種
Full Name cyclin D1
Calculated molecular weight 295 aa, 34 kDa
Observed molecular weight 34 kDa
GenBank accession numberBC000076
Gene Symbol Cyclin D1
Gene ID (NCBI) 595
RRIDAB_10793718
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP24385
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CCND1 (cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma (MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

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