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DHCR24 Monoclonal antibody, PBS Only (Detector)

DHCR24 Monoclonal Antibody for WB, IHC, Cytometric bead array, Indirect ELISA
Cat No. 60028-1-PBS
Clone No.2F6E11

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, IHC, Cytometric bead array, Indirect ELISA

DHC24, EC:1.3.1.72, Delta(24)-sterol reductase, 3-beta-hydroxysterol Delta-24-reductase, 2F6E11

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -


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約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

60028-1-PBS targets DHCR24 as part of a matched antibody pair:

MP51020-1: 60028-2-PBS capture and 60028-1-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen DHCR24 fusion protein Ag0756 相同性解析による交差性が予測される生物種
Full Name 24-dehydrocholesterol reductase
Calculated molecular weight 60 kDa, 516 aa
Observed molecular weight 60 kDa
GenBank accession numberBC004375
Gene Symbol DHCR24
Gene ID (NCBI) 1718
RRIDAB_874115
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ15392
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

DHCR24(3-beta-hydroxysterol delta-24-reductase), also named as Seladin-1 or Diminuto/dwarf1 homolog, is a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, and catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The dhcr24 expression was shown to be down regulated in brain areas affected by Alzheimer's disease and endogenous DHCR24/seladin-1 levels are highly up-regulated upon acute oxidative stress while expression declines to very low levels upon chronic exposure (PMID:17984220). In apoptotic cells, endogenous seladin-1 was cleaved to a 40 kDa derivative in a caspase-dependent manner (PMID: 11007892).

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