DNMT1 Monoclonal antibody, PBS Only
DNMT1 Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse, Rat
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2G5C5
Cat no : 68485-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
68485-1-PBS targets DNMT1 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
Tested Reactivity | Human, Mouse, Rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | DNMT1 fusion protein Ag19116 相同性解析による交差性が予測される生物種 |
Full Name | DNA (cytosine-5-)-methyltransferase 1 |
Calculated molecular weight | 1632 aa, 185 kDa |
Observed molecular weight | 180-200 kDa |
GenBank accession number | BC126227 |
Gene symbol | DNMT1 |
Gene ID (NCBI) | 1786 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
DNA methylation is a major epigenetic modification that regulates gene expression. DNMT1, the maintenance DNA methylation enzyme, is the primary enzyme responsible for copying methylation patterns after DNA replication. DNMT1 is required for X chromosome inactivation, imprinting, genomic methylation and proper embryonic development. Overexpression of DNMT1 has been reported in various cancers. DNMT1 exists some isoforms with MW 184 kDa and 145 kDa. (PMID: 10753866)