Validation Data Gallery
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Tested Applications
| Positive WB detected in | mouse thymus tissue, human placenta tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 1 publications below |
| WB | See 4 publications below |
Product Information
10650-1-AP targets DPP3 in WB, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | DPP3 fusion protein Ag1022 相同性解析による交差性が予測される生物種 |
| Full Name | dipeptidyl-peptidase 3 |
| Calculated molecular weight | 83 kDa |
| Observed molecular weight | 69 kDa, 83 kDa |
| GenBank accession number | BC007221 |
| Gene Symbol | DPP3 |
| Gene ID (NCBI) | 10072 |
| RRID | AB_2093553 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9NY33 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
DPP3 (dipeptidyl-peptidase 3), also known as DPPIII, is one of the dipeptidyl aminopeptidases, that belongs to the peptidase M49 family. DPP3 is a metalloenzyme containing one Zn2+ ion in its active site. Furthermore, It was shown to have a novel zinc-binding motif ( HELLGH). DPP3 has been reported as an important enkephalin-degrading enzyme in the central nervous system, in human neutrophils.It has 3 isoforms produced by alternative splicing. Increased activity of DPP3 is associated with endometrial and ovarian cancers.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for DPP3 antibody 10650-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
J Biol Chem Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
| ||
Environ Mol Mutagen Proteomic biomarkers for prenatal bisphenol A-exposure in mouse immune organs. | ||
Int Immunopharmacol Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway | ||
J Biol Chem The Serine Protease DPP9 and the Redox Sensor KEAP1 Form a Mutually Inhibitory Complex |