Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
30493-1-PBS targets DUSP10 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | DUSP10 fusion protein Ag32718 相同性解析による交差性が予測される生物種 |
| Full Name | dual specificity phosphatase 10 |
| Observed molecular weight | 53 kDa |
| GenBank accession number | BC031405 |
| Gene Symbol | DUSP10 |
| Gene ID (NCBI) | 11221 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9Y6W6 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
DUSP10, also known as MKP5, is a member of the MKPs subfamily involved in cell proliferation, differentiation, and migration. DUSP10 is a dual specificity phosphatase capable of dephosphorylating both pTyr and pThr residues of activated MAPKs with different affinities. It has been shown that isoforms of the p38 and JNK subfamilies are selectively and more effectively dephosphorylated than ERK subfamily members. DUSP10 has been proposed as a target for therapeutic treatment of atherosclerosis, since DUSP10 inhibition reduces NF-κB-induced TNF-α expression and increases TGF-β1 levels in this disease (PMID: 30939861).