DUSP6 Polyclonal antibody

DUSP6 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 10433-1-AP

Synonyms

dual specificity phosphatase 6, DUSP6, MAP kinase phosphatase 3, MKP 3, MKP3, PYST1


☆対象製品が30%オフ!組換えタンパク質&免染用試薬 >>> キャンペーン実施中!


Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10433-1-AP targets DUSP6 in WB, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DUSP6 fusion protein Ag0705 相同性解析による交差性が予測される生物種
Full Name dual specificity phosphatase 6
Calculated molecular weight42 kDa
GenBank accession numberBC003562
Gene symbol DUSP6
Gene ID (NCBI) 1848
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).

Publications

SpeciesApplicationTitle
humanWB

Br J Pharmacol

L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia.

Authors - Yi-Ping Leng
mouseWB

Ren Fail

LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis

Authors - Taoxia Wang
mouseWB

Mol Cell Biochem

PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.

Authors - Jeong Hyo-Soon HS
humanIHC

Chin Med J (Engl)

Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma.

Authors - Bo Yang
ratWB

Biochim Biophys Acta

VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.

Authors - Kang Tae-Hong TH