Anti-Mouse E-Cadherin Rabbit Recombinant Antibody

E-Cadherin Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

mouse, canine

Applications

FC

Conjugate

Unconjugated

CloneNo.

241282C1

Cat no : 98140-1-RR

Synonyms

Um, L CAM, Ecad, Cdh1, cadherin 1


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Tested Applications

Positive FC detected inMDCK cells

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 98140-1-RR is E-Cadherin Fusion Protein expressed in E. coli.

Tested Reactivity mouse, canine
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Fusion Protein 相同性解析による交差性が予測される生物種
Full Name cadherin 1
Calculated molecular weight98kDa
GenBank accession numberNM_009864.3
Gene symbol E-cadherin
Gene ID (NCBI) 12550
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

Background Information

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CD324, CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.

Protocols

Product Specific Protocols
FC protocol for E-Cadherin antibody 98140-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols