E2F8 Polyclonal antibody, PBS Only
E2F8 Polyclonal Antibody for WB, IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IP, Indirect ELISA
Conjugate
Unconjugated
Cat no : 13425-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
13425-1-PBS targets E2F8 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | E2F8 fusion protein Ag4216 相同性解析による交差性が予測される生物種 |
Full Name | E2F transcription factor 8 |
Calculated molecular weight | 867 aa, 94 kDa |
Observed molecular weight | 105 kDa |
GenBank accession number | BC028244 |
Gene symbol | E2F8 |
Gene ID (NCBI) | 79733 |
RRID | AB_2097273 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
E2F8 is one E2F transcription factor that is essential for orchestrating expression of genes required for cell cycle progression, proliferation, apoptosis and differentiation. E2F8 shows a high degree of resemblance to E2F7 and shares the unique structure of E2F7 by having two distinct domains exhibiting a high degree of similarity to the DNA-binding domain of the E2F familyTogether with E2F7, they possess two DNA-binding domains that are predicted to interact with each other. E2F8 binds consensus E2F sites in a DP-independent manner and represses transcription of E2F-regulated promoters. Ectopic expression of E2F8 inhibits cellular proliferation. The calcualted molecular weight of E2F8 is 94 kDa, but modified E2F8 is about 105 kDa. (PMID: 15897886)