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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using EMR2 Recombinant antibody (84608-5-RR)

    WB analysis using 84608-5-RR

    Various lysates were subjected to SDS PAGE followed by western blot with 84608-5-RR (EMR2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

  • Affinity and Kinetic Characterization of 84608-5-RR

    Affinity and Kinetic Characterization of 84608-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84608-5-RR against Human EMR2 were performed. The affinity constant is 1.45 nM.

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EMR2 Recombinant antibody

EMR2 Recombinant Antibody for WB, ELISA
Cat No. 84608-5-RR
Clone No.242042E3

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

EGF-like module receptor 2, EGF like module receptor 2, CD312, Adhesion G protein-coupled receptor E2, ADGRE2

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inHeLa cells, THP-1 cells, L02 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:2000-1:10000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

84608-5-RR targets EMR2 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name egf-like module containing, mucin-like, hormone receptor-like 2
Calculated molecular weight90 kDa
Observed molecular weight75~90 kDa
GenBank accession numberNM_013447.3
Gene Symbol EMR2
Gene ID (NCBI) 30817
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ9UHX3-1
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

EMR2 (Epidermal Growth Factor-like module-containing Mucin-like Hormone Receptor 2), also known as ADGRE2, is a member of the adhesion-GPCR family that contains extracellular EGF-like domains. EMR2 contains a total of five tandem EGF-like domains and expresses similar protein isoforms consisting of various numbers of EGF-like domains as a result of alternative RNA splicing (PMID: 10903844). EMR2 is restricted to myeloid cells including monocytes, macrophages, dendritic cells and granulocytes28 and its expression is highly regulated during monocyte/macrophage differentiation (PMID: 31969668).The ligation of EMR2 could increase neutrophil adhesion, migration and anti-microbial mediator production and could enhance the systemic inflammation (PMID: 27905560).

Protocols

Product Specific Protocols
WB protocol for EMR2 antibody 84608-5-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols