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Validation Data Gallery

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  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human Endoglin/CD105 Rabbit Recombinant Antib (98013-2-RR)

    FC experiment of human PBMCs using 98013-2-RR (same clone as 98013-2-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human Endoglin/CD105 Rabbit Recombinant Antibody (98013-2-RR, Clone: 241196D9) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98013-2-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human Endoglin/CD105 Rabbit Recombinant Antib (98013-2-RR)

    FC experiment of human PBMCs using 98013-2-RR (same clone as 98013-2-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human Endoglin/CD105 Rabbit Recombinant Antibody (98013-2-RR, Clone: 241196D9) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98013-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98013-2-RR

    Affinity and Kinetic Characterization of 98013-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98013-2-RR against Human Endoglin/CD105 were performed. The affinity constant is 0.234 nM.

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Anti-Human Endoglin/CD105 Rabbit Recombinant Antibody, PBS Only

Endoglin/CD105 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98013-2-PBS
Clone No.241196D9

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD105, 241196D9, HHT1, ENG, Endoglin

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

98013-2-PBS targets Endoglin/CD105 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Fusion Protein 相同性解析による交差性が予測される生物種
Full Name endoglin
Calculated molecular weight 71 kDa
GenBank accession numberBC014271
Gene Symbol CD105
Gene ID (NCBI) 2022
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP17813
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodeling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)