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  • KD/KO Validated

FAM107A Polyclonal antibody

FAM107A Polyclonal Antibody for IHC, IF/ICC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, IF/ICC, ELISA

Conjugate

Unconjugated

Cat no : 12176-1-AP

Synonyms

TU3A, DRR1, Down-regulated in renal cell carcinoma 1


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Tested Applications

Positive IHC detected inhuman lung cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inMCF-7 cells

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)/ICCIF/ICC : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12176-1-AP targets FAM107A in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FAM107A fusion protein Ag2820 相同性解析による交差性が予測される生物種
Full Name family with sequence similarity 107, member A
Calculated molecular weight 144 aa, 17 kDa
GenBank accession numberBC010561
Gene symbol FAM107A
Gene ID (NCBI) 11170
RRIDAB_2877832
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

FAM107A, also named as TU3A, encodes a 144 amino-acid protein, which contains a coiled-coil domain and a nuclear localization signal. FAM107A as a transcription factor regulates some gene transcription and signal transduction in cell. With the exception of peripheral blood cells, FAM107A is widely expressed in normal tissues, but shows significant loss of expression in renal cell carcinomas and frequent loss of expression in cervical, gastric, ovarian and non small cell lung cancers. Transfection of FAM107A mRNA into cancer cell line inhibits cell growth and proliferation, supporting the evidence that the gene functions as an important tumor suppressor.

Protocols

Product Specific Protocols
IHC protocol for FAM107A antibody 12176-1-APDownload protocol
IF protocol for FAM107A antibody 12176-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Hum Mol Genet

A severe mouse model of spinal muscular atrophy develops early systemic inflammation.

Authors - Bo Wan
humanWB

Front Mol Neurosci

PMID: 29632473

Authors - Jian Zhang
mouseWB,IF

Arch Biochem Biophys

Loss of family with sequence similarity 107, member A (FAM107A) induces browning in 3T3-L1 adipocytes.

Authors - Subramani Manigandan
  • KD Validated
humanWB,IHC

Cancers (Basel)

FAM107A Inactivation Associated with Promoter Methylation Affects Prostate Cancer Progression through the FAK/PI3K/AKT Pathway

Authors - Shuai Ke
humanWB,IHC

Pathol Res Pract

FAM107A as a tumor suppressor in esophageal squamous carcinoma inhibits growth and metastasis

Authors - Jiale Zhang