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FceR1a Polyclonal antibody

FceR1a Polyclonal Antibody for WB, ELISA
Cat No. 10980-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, ELISA

IgE Fc receptor subunit alpha, FceRIa, FcERI, Fc-epsilon RI-alpha, FCE1A

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -


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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inMC/9 cells, human spleen tissue, RAW 264.7 cells, mouse spleen tissue, rat spleen tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10980-1-AP targets FceR1a in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FceR1a fusion protein Ag1398 相同性解析による交差性が予測される生物種
Full Name Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Calculated molecular weight 30 kDa
Observed molecular weight 55-70 kDa
GenBank accession numberBC015195
Gene Symbol FceR1a
Gene ID (NCBI) 2205
RRIDAB_2103033
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP12319
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Fc epsilon Receptor I alpha (FceR1a) is a single-pass type I membrane protein that contains 2 immunoglobulin-like domains. FceR1a forms a tetrameric complex, FceRI, with one beta and two gamma subunits (PMID: 19406478). FceRI is the high-affinity receptor for the Fc region of immunoglobulin E (IgE) (PMID: 1532373). It is expressed on mast cells and basophils and plays a central role in the allergic response (PMID: 2148316). The calculated molecular weight of FceR1a is 30 kDa, the 55- to 70-kDa bands detected by this antibody are probably caused by heterogeneous glycosylation (PMID: 11344350; 12671054).

Protocols

Product Specific Protocols
WB protocol for FceR1a antibody 10980-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseIF

Science

Response to Comment on "Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression".

Authors - Sachiko Taniguchi
humanIHC

J Allergy Clin Immunol

Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma.

Authors - Andersson Cecilia K CK
humanWB

J Allergy Clin Immunol

Thymic stromal lymphopoietin epigenetically upregulates Fc receptor γ subunit-related receptors on antigen-presenting cells and induces TH2/TH17 polarization through dectin-2.

Authors - Yunsheng Liang
mouseWB

Transl Res

Allergic asthma aggravates angiotensin Ⅱ-induced cardiac remodeling in mice.

Authors - Chi Geng
  • KO Validated
mouseWB

Theranostics

Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p.

Authors - Hongmei Zhao
humanIHC

Thorax

Novel site-specific mast cell subpopulations in the human lung.

Authors - Andersson C K CK
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