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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using GSDMC Polyclonal antibody (30469-1-AP)

    WB analysis using 30469-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 30469-1-AP (GSDMC antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of various lysates using GSDMC Polyclonal antibody (30469-1-AP)

    WB analysis using 30469-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 30469-1-AP (GSDMC antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of Human bowens disease using GSDMC Polyclonal antibody (30469-1-AP)

    IHC staining of Human bowens disease using 30469-1-AP

    Immunohistochemical analysis of paraffin-embedded human brown disease slide using 30469-1-AP (GSDMC antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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GSDMC Polyclonal antibody

GSDMC Polyclonal Antibody for WB, IHC, ELISA
Cat No. 30469-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, ELISA

Synonyms

Gasdermin-C, MLZE, gasdermin C

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inMDA-MB-231 cells, HCT 116 cells, A375 cells
Positive IHC detected inHuman bowens disease
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
Immunohistochemistry (IHC)IHC : 1:300-1:1200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

30469-1-AP targets GSDMC in WB, IHC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GSDMC fusion protein Ag33319 相同性解析による交差性が予測される生物種
Full Name gasdermin C
Calculated molecular weight58kd
Observed molecular weight58 kDa
GenBank accession numberNM_031415
Gene Symbol GSDMC
Gene ID (NCBI) 56169
RRIDAB_3086329
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9BYG8
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Gasdermin (GSDM) superfamily consists of Gasdermin family genes (GSDMA, GSDMB, GSDMC and GSDMD in humans) and Gasdermin-related genes (DFNA5, DFNB59 in humans). GSDM family members were shown to be detected in the epithelium of various tissue types in a highly tissue-specific manner and suggested to have differentiation-status specific roles. Gasdermin C (GSDMC) was known as melanoma-derived leucine zipper-containing extranuclear factor (MLZE). Several studies have suggested that GSDMC may be involved in the course of tumorigenesis such as acquisition of metastatic potential in melanoma cells or promotion of cell proliferation in colorectal carcinogenesis and that GSDMC may function as an oncogene. (PMID: 29428815)

Protocols

Product Specific Protocols
WB protocol for GSDMC antibody 30469-1-APDownload protocol
IHC protocol for GSDMC antibody 30469-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols