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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

KIM-1/HAVCR1 Polyclonal antibody

HAVCR1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat no : 26420-1-AP

Synonyms

CD365, HAVCR, HAVCR 1, HAVCR1, Kidney injury molecule 1, KIM 1, KIM1, T cell membrane protein 1, TIM, TIM 1, TIM1, TIMD 1, TIMD1

Validation Data Gallery

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  • Western Blot (WB) analysis of A549 cells using HAVCR1 Polyclonal antibody (26420-1-AP)

    WB analysis of A549 using 26420-1-AP

    A549 cells were subjected to SDS PAGE followed by western blot with 26420-1-AP (HAVCR1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of human renal cell carcinoma tissue using HAVCR1 Polyclonal antibody (26420-1-AP)

    IHC staining of human renal cell carcinoma using 26420-1-AP

    Immunohistochemical analysis of paraffin-embedded human renal cell carcinoma tissue slide using 26420-1-AP (HAVCR1 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human renal cell carcinoma tissue using HAVCR1 Polyclonal antibody (26420-1-AP)

    IHC staining of human renal cell carcinoma using 26420-1-AP

    Immunohistochemical analysis of paraffin-embedded human renal cell carcinoma tissue slide using 26420-1-AP (HAVCR1 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 26420-1-AP is HAVCR1 Fusion Protein expressed in E. coli.

Tested Reactivity human
Cited Reactivitymouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen HAVCR1 fusion protein Ag23888 相同性解析による交差性が予測される生物種
Full Name hepatitis A virus cellular receptor 1
Calculated molecular weight 359 aa, 39 kDa
GenBank accession numberBC013325
Gene symbol HAVCR1
Gene ID (NCBI) 26762
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Hepatitis A virus cellular receptor 1 (HAVCR1, also known as TIM-1, KIM-1 or CD365) is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. HAVCR1 acts as a membrane receptor for hepatitis A virus (HHAV) (PMID: 9658108; 8861957). HAVCR1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). HAVCR1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that HAVCR1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).

Publications

SpeciesApplicationTitle
mouseIHC,IF

Drug Deliv

Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury.

Authors - Jing-Bo Hu
View Article
mouseIHC

Redox Biol

Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1

Authors - Yijian Deng
View Article