HER2/ErbB2 Monoclonal antibody, PBS Only
HER2/ErbB2 Monoclonal Antibody for IHC, IF-P, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
human
Applications
IHC, IF-P, ELISA
Conjugate
Unconjugated
CloneNo.
1B12A7
Cat no : 60311-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
60311-1-PBS targets HER2/ErbB2 in IHC, IF-P, ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | HER2/ErbB2 fusion protein Ag16463 相同性解析による交差性が予測される生物種 |
Full Name | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
Calculated molecular weight | 1255 aa, 138 kDa |
GenBank accession number | BC156755 |
Gene symbol | HER2/ErbB2 |
Gene ID (NCBI) | 2064 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
HER2, ErbB2, and Neu is a 185-kDa transmembrane glycoprotein member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand-binding domain and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.